高玉兴
个人简历:
2000~2004 曲阜师范大学化学化工学院,化学系,本科
2004~2007 厦门大学化学系,获理学硕士
2007~2010 厦门大学化学系,有机化学专业,获理学博士
2011.4~2018.6 厦门大学化学化工学院,工程师
2018.7~至今 厦门大学化学化工学院,高级工程师
研究方向:
主要从事有机合成化学和精细化学品清洁生产新工艺研究。在均相催化的选择性控制与多样性合成方法学,含磷生物活性分子、药物及功能性分子的设计与合成工艺开发等领域具研究特长,是厦门大学有机化学研究所的研究成员。
已研发应用成功的精细化学品工艺包括3,3,3-三氟丙酸清洁生产新工艺、三氟甲基三甲基硅烷生产新工艺、正溴辛烷清洁生产新工艺、栀子蓝生产新工艺以及4,4-二溴联苯清洁生产新工艺等。
承担科研项目:
横向基金项目,3,3,3-三氟丙酸及三氟甲基三甲基硅烷等合成工艺开发,2021/11-2023/11,120万元,在研,主持。
横向基金项目,有机氟化合物的合成和检测服务,2021/4-2022/4,10万元,在研,主持。福建省海洋经济发展补助资金项目( FJHJF-L-2018-2),环保型海洋防污涂料的关键技术研发及示范应用,2018/6-2020/6,668.6万元,已结题,主要参与人。
厦门大学校长基金项目,20720180083,新型亲油性沙蚕毒素衍生物的合成及其在海洋防污涂料中的应用,2018/1-2018/12,10万元,已结题,主持。
横向基金项目,天然色素研究和检测服务,2018/3-2019/2,10万元,在研,主持。
国家自然科学基金-应急管理项目,21642010,功能性含P-C键的五元、六元及七元磷杂环化合物的高效合成新方法研究, 2017/1-2017/12,10万元,已结题,主持。
国家自然科学基金青年基金项目,21202135,高效构建含P-C键的功能有机膦化合物的新方法研究,2013/1-2015/12,25万元,已结题,主持。
福建省自然科学基金青年基金项目,2013J05031,锂离子电池电解液新型含磷阻燃剂的合成与应用,4.00 万元,2013/1-2015/12,已结题,主持。
横向基金项目,天然色素的分离和检测服务,2014/7-2018/2,25万元,主持,已结题。
横向基金项目,新型布雷菲得菌素A(BrefeldinA)类肿瘤先导化合物的设计、合成及筛选,2011/12-2012/12,5 万元,已结题,主持。
主要代表论著:
Baffa Haruna, Weitu Hong, Warsame Ibrahim Mohamed, Jiami Guo, Liyi Ye, Yingwu Yin, Yuxing Gao,* and Song Tu* Visible-Light-Induced Oxidative C−H Functionalization of Unreactive Cycloalkanes, Alcohols, and Ethers with Alkynylphosphine Oxides into Benzo[b]phosphole Oxides under Photocatalyst‑, Metal‑, and Base-Free Conditions J. Org. Chem. 2021, 86, 13092−13099.
Shanshan Hu, Wenyu Sun, Junhong Chen, Sipei Li, Runmin Zhao, Pengxiang Xu,* Yuxing Gao* and Yufen Zhao Palladium-catalyzed C–P cross-coupling of allenic alcohols with H-phosphonates leading to 2-phosphinoyl-1,3-butadienes Chem. Commun., 2021, 57, 339—342.
Dumei Ma, Shanshan Hu, Sirui Chen, Jiaoting Pan, Song Tu, Yingwu Yin,* Yuxing Gao,*and Yufen Zhao Palladium-Catalyzed Addition/Cyclization of (2-Hydroxyaryl)boronic Acids with Alkynylphosphonates: Access to Phosphacoumarins Org. Lett. 2020, 22, 8156−8160.
Jiami Guo, Chenlu Mao, Bin Deng, Liyi Ye, Yingwu Yin, Yuxing Gao,* and Song Tu* Azobisisobutyronitrile-Initiated Oxidative C−H Functionalization of Simple Alcohols with Diaryl(arylethynyl)phosphine Oxides: A Metal-Free Approach toward Hydroxymethyl Benzo[b]phosphole Oxides and 6H‑Indeno[2,1‑b]phosphindole 5‑Oxide Derivatives J. Org. Chem. 2020, 85, 6359−6371.
Jiaoting Pan, Runmin Zhao, Jiami Guo, Dumei Ma, Ying Xia, Yuxing Gao,* Pengxiang Xu*, Yufen Zhao. Three-component 3-(phosphoryl)methylindole synthesis from indoles, H-phosphine oxides and carbonyl compounds under metal-free conditions. Green Chem. 2019, 24(4), 792–797.
Fushan Chen, Ying Xia, Rongcan Lin, Yuxing Gao,* Pengxiang Xu,* Yufen Zhao. Copper-Catalyzed Direct Twofold C–P Cross-Coupling of Unprotected Propargylic 1,4-Diols: Access to 2,3-Bis(diarylphosphynyl)-1,3-butadienes. Org. Lett. 2019, 21(2), 579−583.
Dumei Ma, Jiaoting Pan, Lu Yin, Pengxiang Xu, Yuxing Gao,* Yingwu Yin, Yufen Zhao. Copper-Catalyzed Direct Oxidative C−H Functionalization of Unactivated Cycloalkanes into Cycloalkyl Benzo[b]phosphole Oxides. Org. Lett., 2018, 20, 3455−3459. (If 6.36)
Changkai Shan, Fushan Chen, Jiaoting Pan, Yuxing Gao,* Pengxiang Xu,* Yufen Zhao. Zn(OTf)2‑Catalyzed Phosphinylation of Propargylic Alcohols: Access to γ‑Ketophosphine Oxides. J. Org. Chem. 2017, 82, 11659−11666. (If 4.85)
Gaobo Hu, Changkai Shan, Weizhu Chen, Pengxiang Xu, Yuxing Gao,* Yufen Zhao. Copper-Catalyzed Direct Coupling of Unprotected Propargylic Alcohols with P(O)H Compounds: Access to Allenylphosphoryl Compounds under Ligand- and Base-Free Conditions Org. Lett., 2016, 18, 6066-6069. (If 6.36)
Dumei Ma, Weizhu Chen, Gaobo Hu, Yun Zhang, Yuxing Gao,* Yingwu Yin, Yufen Zhao. K2S2O8-mediated metal-free direct P-H/C-H functionalization: a convenient route to benzo[b]phosphole oxides from unactivated alkynes. Green Chem., 2016, 18, 3522.
Yun Zhang, Gaobo Hu, Dumei Ma, Pengxiang Xu, Yuxing Gao*, Yufen Zhao. TBAI-catalyzed oxidative C–H functionalization: a new route to benzo[b]phosphole oxides. Chem. Commun., 2016, 52, 2815-2818.
Gaobo Hu, Weizhu Chen, Dumei Ma, Yun Zhang, Pengxiang Xu, Yuxing Gao*, Yufen Zhao. Silver-Catalyzed, Aldehyde Induced α-C–H Functionalization of Tetrahydroisoquinolines with Concurrent C–P Bond Formation/N-Alkylation. J. Org. Chem, 2016, 81, 1704-1711.
Gaobo Hu, Yuxing Gao*, Yufen Zhao. Copper-Catalyzed Decarboxylative C-P Cross-coupling of Alkynyl Acids with H-phosphine Oxides: A Facile and Selective Synthesis of (E)-1-Alkenylphosphine Oxides. Org. Lett., 2014, 16, 4464-4467.
Gaobo Hu, Yun Zhang, Jue Su, Zezhou Li, Yuxing Gao*, Yufen Zhao. Ag-mediated cascade decarboxylative coupling and annulation: a convenient route 2-phosphinobenzo[b]phosphosphole oxides. Org. Biomol. Chem., 2015, 13, 8221-8231.
Yuxing Gao*, Honggui Deng, Shanshan Zhang, Wanhua Xue, Yile Wu, Hongwei Qiao, Pengxiang Xu*, Yufen Zhao. Nickel-catalyzed one-pot tandem 1,4-1,2-addition of P(O)H compounds to 1,10-phenanthrolines. J. Org. Chem., 2015, 80, 1192−1199.
Wentao Xu, Gaobo Hu, Pengxiang Xu, Yuxing Gao*, Yingwu Yin*, Yufen Zhao. Palladium-catalyzed C-P Cross-coupling of Arylhydrazines with H-phosphonates via C-N Bond Cleavage. Adv. Synth. Catal., 2014, 356, 2948-2954.
Gaobo Hu, Weizhu Chen, Tingting Fu, Zhimin Peng, Hongwei Qiao, Yuxing Gao*, Yufen Zhao. Nickel-Catalyzed C-P Cross-Coupling of Arylboronic Acids with P(O)H Compounds. Org. Lett., 2013, 15, 5362-5365.
Tao Wang, Shuai Sang, Liu Liu, Hongwei Qiao, Yuxing Gao*, Yufen Zhao. Experimental and Theoretical Study on Palladium-Catalyzed C−P Bond Formation via Direct Coupling of Triarylbismuths with P(O)-H Compounds. J. Org. Chem., 2014, 79, 608-617.
Ye Lv, Gaobo Hu, Dumei Ma, Liu Liu, Yuxing Gao*, Yufen Zhao. Palladium-catalyzed Domino Addition and Cyclization of Arylboronic Acids with 3-Hydroxyprop-1-yn-1-yl Phosphonates Leading to 1,2-Oxaphospholenes J. Org. Chem., 2015, 80,6908-6914.
Yile Wu, Liu Liu, Jue Su, Kaili Yan, Tao Wang, Jun Zhu, Xiang Gao, Yuxing Gao*, Yufen Zhao. Reactivity of Germylene towards Phosphorus-Containing Compounds: Nucleophilic Addition and Tautomerism. Inorg. Chem., 2015, 54, 4423−4430.
Yile Wu, Liu Liu, Kaili Yan, Pengxiang Xu, Yuxing Gao*, Yufen Zhao. Nickel-Catalyzed Decarboxylative C-P Cross-Coupling of Alkenyl Acids with P(O)H Compounds. J. Org. Chem., 2014, 79, 8118-8127.
Zhimin Peng, Gaobo Hu, Hongwei Qiao, Pengxiang Xu*, Yuxing Gao*, Yufen Zhao. Palladium-catalyzed Suzuki Cross-coupling of Arylhydrazines via C-N Bond Cleavage. J. Org. Chem., 2014, 79, 2733-2738.
Tingting Fu, Hongwei Qiao, Zhimin Peng, Gaobo Hu, Xueji Wu, Yuxing Gao*, Yufen Zhao. Palladium-catalyzed air-based oxidative coupling of arylboronic acids with H-phosphine oxides leading to aryl phosphine oxides. Org. Biomol. Chem., 2014, 12, 2895-2902.
Liu Liu, Ye Lv, Yile Wu, Xiang Gao, Zhiping Zeng, Yuxing Gao*, Guo Tang*, Yufen Zhao. Experimental and Theoretical Studies on Nickel-Zinc-Catalyzed Cross-Coupling of gem-Dibromoalkenes with P(O)-H Compounds. RSC Adv., 2014, 4, 2322-2326.
Yulei Wang, Jiepeng Gan, Liu Liu, Hang Yuan, Yuxing Gao,* Yan Liu,* Yufen Zhao. Cs2CO3-Promoted One-Pot Synthesis of Alkynylphosphonates, -phosphinates, and -phosphine Oxides. J. Org. Chem., 2014, 79, 3678-3683.
Liu Liu, Yulei Wang, Zhiping Zeng, Pengxiang Xu, Yuxing Gao*, Yingwu Yin*, Yufen Zhao. Nickel(II)-Magnesium catalyzed cross-coupling of 1,1-Dibromo-1-Alkenes with Diphenylphosphine Oxide: One-Pot Synthesis of (E)-1-Alkenylphosphine Oxides or Bisphosphine Oxides. Adv. Synth. Catal., 2013, 355, 659-666.
Zengxiang Zhao, Wanhua Xue, Yuxing Gao, Guo Tang*, Yufen Zhao. Copper-Catalyzed Synthesis of a-Hydroxy Phosphonates from H-Phosphonates and Alcohols or Ethers. Chem. Asian J., 2013, 8, 713-716.
Yonghua Lai, Chen, Liangsen Chen, Weichao Bao, Yihua, Ren, Yuxing Gao, Yingwu Yin*, Yufen Zhao. Glycine-Mediated, Selective Preparation of Monodisperse Spherical Vaterite Calcium Carbonate in Various Reaction Systems. Cryst. Growth Des., 2013, 15 (3), 1194-1200.
Xiubin Li, Gaobo Hu, Ping Luo, Guo Tang, Yuxing Gao,* Pengxiang Xu,* Yufen Zhao. Palladium(II)-Catalyzed Hydration of Alkynylphosphonates to β-ketophosphonates. Adv. Synth. Catal., 2012, 354, 2427-2432.
Yu-Xing Gao, Guo Tang*, Yu Cao, Yu-Fen Zhao*, A Novel and General Method for the Formation of S-Aryl, Se-Aryl, and Te-Aryl Phosphorochalcogenoates. Synthesis 2009, 7, 1081-6.
Xunfu Xu, Hu Chen*, Yulei Wang, Yuxing Gao, Guo Tang*, Yufen Zhao. Catalyst-free synthesis of cycloalkenyl phosphonates. RSC Adv., 2014, 4, 14740-14743.
Yong-Bo Zhou, Shuang-Feng Yin, Yu-Xing Gao, Yu-Fen Zhao, Midori Goto, and Li-Biao Han*. Selective P-P and P-O-P Bond Formations through Copper-Catalyzed Aerobic Oxidative Dehydrogenative Couplings of H-Phosphonates. Angew. Chem. Int. Ed. 2010, 49, 6852 –6855.
Yuxing Gao, Gang Wang, Lu Chen, Pengxiang Xu, Yufen Zhao*, Yongbo Zhou, Li-Biao Han*. Copper-Catalyzed Aerobic Oxidative Coupling of Terminal Alkynes with H-Phosphonates Leading to Alkynylphosphonates. J. Am. Chem. Soc. 2009, 131, 7956-7957。
Weizhu Chen, Dumei Ma, Gaobo Hu, Zhuan Hong, Yuxing Gao*, Yufen Zhao Copper-catalyzed decarboxylative C−P cross coupling of arylpropiolic acids with dialkyl hydrazinylphosphonates leading to alkynylphosphonates. Synthetic Commun., 2016, 46, 1171-1181.
厦门大学博士
E-mail:gaoxingchem@xmu.edu.cn